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pentobarbital will minimize the extent or result of parecoxib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.pentobarbital will decrease the level or influence of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with solid CYP3A4 inducers will not be propose